BDBM50248442 2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(4-methylthiazol-2-yl)benzamide::2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide::CHEMBL489514

SMILES Cc1csc(NC(=O)c2cc(Sc3nncn3C)ccc2N)n1

InChI Key InChIKey=JEBOJMQHVUEKBE-UHFFFAOYSA-N

Data  1 Kd  6 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50248442   

TargetHexokinase-4(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50248442(2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(...)
Affinity DataKd:  440nMAssay Description:Binding affinity to recombinant wild-type human pancreatic glucokinase expressed in Escherichia coli K-12 at 11 uM by isothermal titration calorimetr...More data for this Ligand-Target Pair
TargetHexokinase-4(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50248442(2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(...)
Affinity DataEC50:  420nMAssay Description:Activation of flag-tagged human recombinant liver glucokinase expressed in Escherichia coli by glucose-6-phosphate dehydrogenase coupled continuous s...More data for this Ligand-Target Pair
TargetHexokinase-4(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50248442(2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(...)
Affinity DataEC50:  140nMAssay Description:Activation of flag-tagged human recombinant liver glucokinase expressed in Escherichia coli by glucose-6-phosphate dehydrogenase coupled continuous s...More data for this Ligand-Target Pair
TargetHexokinase-4(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50248442(2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(...)
Affinity DataEC50:  140nMAssay Description:Activation of N-terminal His-tagged human recombinant liver glucokinase expressed in Escherichia coli BL21 (DE3) by glucose-6-phosphate dehydrogenase...More data for this Ligand-Target Pair
TargetHexokinase-4(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50248442(2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(...)
Affinity DataEC50:  140nMAssay Description:Activation of human glucokinase by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 10 mM glucoseMore data for this Ligand-Target Pair
TargetHexokinase-4(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50248442(2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(...)
Affinity DataEC50:  420nMAssay Description:Activation of N-terminal His-tagged human recombinant liver glucokinase expressed in Escherichia coli BL21 (DE3) by glucose-6-phosphate dehydrogenase...More data for this Ligand-Target Pair
TargetHexokinase-4(Homo sapiens (Human))
Florida State University

Curated by ChEMBL
LigandPNGBDBM50248442(2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(...)
Affinity DataEC50:  420nMAssay Description:Activation of human glucokinase by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 2.5 mM glucoseMore data for this Ligand-Target Pair