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BDBM50248495 CHEMBL490969::N-(pyridin-3-ylmethyl)-2-(1-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)aniline

SMILES: FC(F)(F)c1cccc(c1)-n1cc(nn1)-c1ccccc1NCc1cccnc1

InChI Key: InChIKey=ROHILOOLAQZOCM-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50248495   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50248495
PNG
(CHEMBL490969 | N-(pyridin-3-ylmethyl)-2-(1-(3-(tri...)
Show SMILES FC(F)(F)c1cccc(c1)-n1cc(nn1)-c1ccccc1NCc1cccnc1
Show InChI InChI=1S/C21H16F3N5/c22-21(23,24)16-6-3-7-17(11-16)29-14-20(27-28-29)18-8-1-2-9-19(18)26-13-15-5-4-10-25-12-15/h1-12,14,26H,13H2
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Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF assay in presence of 2 uM ATP


Bioorg Med Chem Lett 19: 1344-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.046
BindingDB Entry DOI: 10.7270/Q2DV1JRT
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50248495
PNG
(CHEMBL490969 | N-(pyridin-3-ylmethyl)-2-(1-(3-(tri...)
Show SMILES FC(F)(F)c1cccc(c1)-n1cc(nn1)-c1ccccc1NCc1cccnc1
Show InChI InChI=1S/C21H16F3N5/c22-21(23,24)16-6-3-7-17(11-16)29-14-20(27-28-29)18-8-1-2-9-19(18)26-13-15-5-4-10-25-12-15/h1-12,14,26H,13H2
PDB
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NCI pathway
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Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGF-induced phosphorylation of VEGFR2 (unknown origin) by cell-based ELISA


Bioorg Med Chem Lett 19: 1344-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.046
BindingDB Entry DOI: 10.7270/Q2DV1JRT
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50248495
PNG
(CHEMBL490969 | N-(pyridin-3-ylmethyl)-2-(1-(3-(tri...)
Show SMILES FC(F)(F)c1cccc(c1)-n1cc(nn1)-c1ccccc1NCc1cccnc1
Show InChI InChI=1S/C21H16F3N5/c22-21(23,24)16-6-3-7-17(11-16)29-14-20(27-28-29)18-8-1-2-9-19(18)26-13-15-5-4-10-25-12-15/h1-12,14,26H,13H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



deCODE

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 (unknown origin) by HTRF assay


Bioorg Med Chem Lett 19: 1344-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.046
BindingDB Entry DOI: 10.7270/Q2DV1JRT
More data for this
Ligand-Target Pair