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BDBM50248889 8-(2,4-Difluoro-phenylamino)-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one::CHEMBL474177

SMILES: Fc1ccc(Nc2ccc3c(c2)ccc2ncccc2c3=O)c(F)c1

InChI Key: InChIKey=VSQHEDJSDFTDQR-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50248889   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50248889
PNG
(8-(2,4-Difluoro-phenylamino)-benzo[4,5]cyclohepta[...)
Show SMILES Fc1ccc(Nc2ccc3c(c2)ccc2ncccc2c3=O)c(F)c1
Show InChI InChI=1S/C20H12F2N2O/c21-13-4-8-19(17(22)11-13)24-14-5-6-15-12(10-14)3-7-18-16(20(15)25)2-1-9-23-18/h1-11,24H
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 330n/an/an/an/an/an/a



Eberhard-Karls-Universität

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAPK (unknown origin) by cell-free enzyme immunosorbent assay


J Med Chem 52: 1778-82 (2009)


Article DOI: 10.1021/jm801291f
BindingDB Entry DOI: 10.7270/Q21836C7
More data for this
Ligand-Target Pair