BDBM50249090 3,3'-(5-fluoropyrimidine-2,4-diyl)bis(azanediyl)diphenol::CHEMBL515271
SMILES Oc1cccc(Nc2ncc(F)c(Nc3cccc(O)c3)n2)c1
InChI Key InChIKey=TVKGTSHBQZEFEE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50249090
Affinity DataKi: 96nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant Syk (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 400nMAssay Description:Inhibition of SYK-mediated PLCgamma phosphorylationMore data for this Ligand-Target Pair
Affinity DataEC50: 400nMAssay Description:Inhibition of SYK-mediated LAT phosphorylationMore data for this Ligand-Target Pair
Affinity DataEC50: 1.58E+3nMAssay Description:Inhibition of SYK assessed as reduction in GM-CSF secretion by cell based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.01E+3nMAssay Description:Inhibition of SYK assessed as reduction in TNFalpha secretion by cell based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 115nMAssay Description:Inhibition of SYK assessed as reduction in LTC4 secretion by cell based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 490nMAssay Description:Inhibition of SYK assessed as reduction in dust mite-induced histamine release by cell based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 353nMAssay Description:Inhibition of SYK assessed as reduction in anti-IgE-mediated tryptase release by cell based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 280nMAssay Description:Inhibition of SYK in human basophils assessed as reduction in anti-IgE-stimulated histamine releaseMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 350nMAssay Description:Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.75E+3nMAssay Description:Inhibition of SYK assessed as reduction in IL8 secretion by cell based assayMore data for this Ligand-Target Pair