BDBM50249421 CHEMBL516060::cyclopropylmethyl 3-isopropyl-1-(5-methyl-1H-pyrazol-3-ylamino)-4-oxo-3,4-dihydrophthalazine-6-carboxylate

SMILES: CC(C)n1nc(Nc2cc(C)n[nH]2)c2ccc(cc2c1=O)C(=O)OCC1CC1

InChI Key: InChIKey=ISFCSFFXAIPUHG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50249421   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50249421 (CHEMBL516060 | cyclopropylmethyl 3-isopropyl-1-(5-...) Show SMILES CC(C)n1nc(Nc2cc(C)n[nH]2)c2ccc(cc2c1=O)C(=O)OCC1CC1 Show InChI InChI=1S/C20H23N5O3/c1-11(2)25-19(26)16-9-14(20(27)28-10-13-4-5-13)6-7-15(16)18(24-25)21-17-8-12(3)22-23-17/h6-9,11,13H,4-5,10H2,1-3H3,(H2,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.99E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of recombinant Syk (unknown origin)				Bioorg Med Chem Lett 19: 1944-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.049 BindingDB Entry DOI: 10.7270/Q2WM1D98
					More data for this Ligand-Target Pair