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BDBM50249421 CHEMBL516060::cyclopropylmethyl 3-isopropyl-1-(5-methyl-1H-pyrazol-3-ylamino)-4-oxo-3,4-dihydrophthalazine-6-carboxylate

SMILES: CC(C)n1nc(Nc2cc(C)n[nH]2)c2ccc(cc2c1=O)C(=O)OCC1CC1

InChI Key: InChIKey=ISFCSFFXAIPUHG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50249421   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50249421
PNG
(CHEMBL516060 | cyclopropylmethyl 3-isopropyl-1-(5-...)
Show SMILES CC(C)n1nc(Nc2cc(C)n[nH]2)c2ccc(cc2c1=O)C(=O)OCC1CC1
Show InChI InChI=1S/C20H23N5O3/c1-11(2)25-19(26)16-9-14(20(27)28-10-13-4-5-13)6-7-15(16)18(24-25)21-17-8-12(3)22-23-17/h6-9,11,13H,4-5,10H2,1-3H3,(H2,21,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.99E+3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Syk (unknown origin)


Bioorg Med Chem Lett 19: 1944-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.049
BindingDB Entry DOI: 10.7270/Q2WM1D98
More data for this
Ligand-Target Pair