BDBM50249479 2-(4-{(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl}piperazin-1-yl)pyrimidine::CHEMBL515387::PF-00734200::cis-(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone

SMILES: FC1(F)CCN(C1)C(=O)[C@@H]1C[C@@H](CN1)N1CCN(CC1)c1ncccn1

InChI Key: InChIKey=QWEWGXUTRTXFRF-UHFFFAOYSA-N

Data: 17 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50249479   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 3A4 (Human)	BDBM50249479 (PF-00734200 | cis-(3,3-Difluoro-pyrrolidin-1-yl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Dipeptidyl peptidase 3 (Human)	BDBM50249479 (PF-00734200 | cis-(3,3-Difluoro-pyrrolidin-1-yl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Amyloid-beta precursor protein (Human)	BDBM50249479 (PF-00734200 | cis-(3,3-Difluoro-pyrrolidin-1-yl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Dipeptidyl peptidase 9 (Human)	BDBM50249479 (PF-00734200 | cis-(3,3-Difluoro-pyrrolidin-1-yl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Prolyl endopeptidase (Human)	BDBM50249479 (PF-00734200 | cis-(3,3-Difluoro-pyrrolidin-1-yl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM50249479 (PF-00734200 | cis-(3,3-Difluoro-pyrrolidin-1-yl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 1A2 (Human)	BDBM50249479 (PF-00734200 | cis-(3,3-Difluoro-pyrrolidin-1-yl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C19 (Human)	BDBM50249479 (PF-00734200 | cis-(3,3-Difluoro-pyrrolidin-1-yl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM50249479 (PF-00734200 | cis-(3,3-Difluoro-pyrrolidin-1-yl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Dipeptidyl peptidase 4 (Human)	BDBM50249479 (PF-00734200 | cis-(3,3-Difluoro-pyrrolidin-1-yl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
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Dipeptidyl peptidase 4 (Rat)	BDBM50249479 (PF-00734200 | cis-(3,3-Difluoro-pyrrolidin-1-yl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
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Dipeptidyl peptidase 4 (Human)	BDBM50249479 (PF-00734200 | cis-(3,3-Difluoro-pyrrolidin-1-yl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Dipeptidyl peptidase 8 (Human)	BDBM50249479 (PF-00734200 | cis-(3,3-Difluoro-pyrrolidin-1-yl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Dipeptidyl peptidase 2 (Human)	BDBM50249479 (PF-00734200 | cis-(3,3-Difluoro-pyrrolidin-1-yl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50249479 (PF-00734200 | cis-(3,3-Difluoro-pyrrolidin-1-yl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.26E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Prolyl endopeptidase FAP (Human)	BDBM50249479 (PF-00734200 | cis-(3,3-Difluoro-pyrrolidin-1-yl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.03E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Dipeptidyl peptidase 4 (Human)	BDBM50249479 (PF-00734200 | cis-(3,3-Difluoro-pyrrolidin-1-yl)-[...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
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