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BDBM50251951 (2S,4S)-2-amino-4-(hydroxymethyl)pentanedioic acid::(2S,4S)-4-(Hydroxymethyl)glutamic Acid::CHEMBL500448

SMILES: N[C@@H](C[C@@H](CO)C(O)=O)C(O)=O

InChI Key: InChIKey=GZEURHPPKFNBRU-IMJSIDKUSA-N

Data: 3 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50251951   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50251951
PNG
((2S,4S)-2-amino-4-(hydroxymethyl)pentanedioic acid...)
Show SMILES N[C@@H](C[C@@H](CO)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO5/c7-4(6(11)12)1-3(2-8)5(9)10/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
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Article
PubMed
3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50251951
PNG
((2S,4S)-2-amino-4-(hydroxymethyl)pentanedioic acid...)
Show SMILES N[C@@H](C[C@@H](CO)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO5/c7-4(6(11)12)1-3(2-8)5(9)10/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
Reactome pathway

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antibodypedia
GoogleScholar
CHEMBL
PC cid
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UniChem

Similars

Article
PubMed
1.40E+5n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT2 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50251951
PNG
((2S,4S)-2-amino-4-(hydroxymethyl)pentanedioic acid...)
Show SMILES N[C@@H](C[C@@H](CO)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO5/c7-4(6(11)12)1-3(2-8)5(9)10/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
Reactome pathway
KEGG

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UniProtKB/TrEMBL

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antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.00E+6n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at EAAT1 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50251951
PNG
((2S,4S)-2-amino-4-(hydroxymethyl)pentanedioic acid...)
Show SMILES N[C@@H](C[C@@H](CO)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO5/c7-4(6(11)12)1-3(2-8)5(9)10/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.00E+6n/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of glutamate-induced depolarization in human human EAAT3 expressed in HEK293 cells by FMP assay


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50251951
PNG
((2S,4S)-2-amino-4-(hydroxymethyl)pentanedioic acid...)
Show SMILES N[C@@H](C[C@@H](CO)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO5/c7-4(6(11)12)1-3(2-8)5(9)10/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.00E+6n/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of glutamate-induced depolarization in human EAAT1 expressed in HEK293 cells by FMP assay


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50251951
PNG
((2S,4S)-2-amino-4-(hydroxymethyl)pentanedioic acid...)
Show SMILES N[C@@H](C[C@@H](CO)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO5/c7-4(6(11)12)1-3(2-8)5(9)10/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.00E+5n/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of glutamate-induced depolarization in human human EAAT2 expressed in HEK293 cells by FMP assay


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair