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BDBM50252602 2-((6,7-dimethoxyquinolin-4-yl)methyl)-1-oxo-N-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide::CHEMBL492857

SMILES: COc1cc2nccc(CN3CCc4c(cccc4C3=O)C(=O)Nc3cccc(c3)C(F)(F)F)c2cc1OC

InChI Key: InChIKey=QDTRRZNAFLCROX-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50252602   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50252602
PNG
(2-((6,7-dimethoxyquinolin-4-yl)methyl)-1-oxo-N-(3-...)
Show SMILES COc1cc2nccc(CN3CCc4c(cccc4C3=O)C(=O)Nc3cccc(c3)C(F)(F)F)c2cc1OC
Show InChI InChI=1S/C29H24F3N3O4/c1-38-25-14-23-17(9-11-33-24(23)15-26(25)39-2)16-35-12-10-20-21(7-4-8-22(20)28(35)37)27(36)34-19-6-3-5-18(13-19)29(30,31)32/h3-9,11,13-15H,10,12,16H2,1-2H3,(H,34,36)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin)


Bioorg Med Chem Lett 18: 4054-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.114
BindingDB Entry DOI: 10.7270/Q2KK9BJG
More data for this
Ligand-Target Pair