BDBM50252876 CHEMBL494462::N,N-Diethyl-4-(spiro[chromene-2,4'-piperidine]-4-yl)benzamide

SMILES CCN(CC)C(=O)c1ccc(cc1)C1=CC2(CCNCC2)Oc2ccccc12

InChI Key InChIKey=WZZXJQIDLWOBDU-UHFFFAOYSA-N

Data  2 KI  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50252876   

TargetDelta-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50252876(CHEMBL494462 | N,N-Diethyl-4-(spiro[chromene-2,4'-...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50252876(CHEMBL494462 | N,N-Diethyl-4-(spiro[chromene-2,4'-...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50252876(CHEMBL494462 | N,N-Diethyl-4-(spiro[chromene-2,4'-...)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human delta opioid receptor in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50252876(CHEMBL494462 | N,N-Diethyl-4-(spiro[chromene-2,4'-...)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of human ERG channel in HEK293 cells by voltage-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50252876(CHEMBL494462 | N,N-Diethyl-4-(spiro[chromene-2,4'-...)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells by voltage clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50252876(CHEMBL494462 | N,N-Diethyl-4-(spiro[chromene-2,4'-...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human CYP2D6 by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50252876(CHEMBL494462 | N,N-Diethyl-4-(spiro[chromene-2,4'-...)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed