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BDBM50254966 (7-(3,5-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)(4-(4-fluorophenyl)piperazin-1-yl)methanone::CHEMBL465124

SMILES: CC1=Nc2ccnn2C(C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1cc(Cl)cc(Cl)c1

InChI Key: InChIKey=WSNQJSLNGCEEPR-UHFFFAOYNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50254966   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254966
PNG
((7-(3,5-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1/C24H22Cl2FN5O/c1-15-22(24(33)31-10-8-30(9-11-31)20-4-2-19(27)3-5-20)23(32-21(29-15)6-7-28-32)16-12-17(25)14-18(26)13-16/h2-7,12-14,22-23H,8-11H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique


Bioorg Med Chem Lett 18: 6381-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7
More data for this
Ligand-Target Pair