BDBM50256480 CHEMBL466397::N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-4-(4-(4-(methylsulfonyl)piperazin-1-yl)piperidin-1-yl)phenylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)-2-methoxybenzamide

SMILES: CCc1cc(Nc2nccc(n2)-c2c(nc3ccccn23)-c2ccc(OC)c(c2)C(=O)Nc2c(F)cccc2F)c(OC)cc1N1CCC(CC1)N1CCN(CC1)S(C)(=O)=O

InChI Key: InChIKey=MOSKATHMXWSZTQ-UHFFFAOYSA-N

Data: 2 KI  12 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 93 hits for monomerid = 50256480   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.88E+3	n/a	n/a	n/a	n/a	n/a	n/a
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High affinity nerve growth factor receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	701	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase FRK (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
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PAS domain-containing serine/threonine-protein kinase (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PAK 3 (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	103	n/a	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase alpha-4 (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.64E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin receptor-related protein (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	488	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase HCK (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	275	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 3 (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	159	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.85E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fes/Fps (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	148	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fer (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
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Focal adhesion kinase 1 (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	362	n/a	n/a	n/a	n/a	n/a	n/a
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Casein kinase I isoform gamma-3 (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase BTK (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	357	n/a	n/a	n/a	n/a	n/a	n/a
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Cytoplasmic tyrosine-protein kinase BMX (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.21E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Aurora kinase A (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	159	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ZAP-70 (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-4 (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 14 (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Aurora kinase A (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
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Aurora kinase B (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Insulin receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Insulin receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Insulin receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Insulin receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Insulin receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Aurora kinase B (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ITK/TSK (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Inhibitor of nuclear factor kappa-B kinase subunit beta (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Inhibitor of nuclear factor kappa-B kinase subunit alpha (Human)	BDBM50256480 (N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
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