BDBM50258287 CHEMBL493169::N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-amine

SMILES FC(F)(F)c1cccc(c1)-c1nnc2ccc(NC3CCNCC3)nn12

InChI Key InChIKey=SENFEQVLOFSJFU-UHFFFAOYSA-N

Data  17 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50258287   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(CHEMBL493169 | N-(piperidin-4-yl)-3-(3-(trifluorom...)
Affinity DataKi:  21nMAssay Description:Inhibition of Pim1 (unknown origin) assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotomet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(CHEMBL493169 | N-(piperidin-4-yl)-3-(3-(trifluorom...)
Affinity DataKi:  800nMAssay Description:Inhibition of Aurora 2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(CHEMBL493169 | N-(piperidin-4-yl)-3-(3-(trifluorom...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(CHEMBL493169 | N-(piperidin-4-yl)-3-(3-(trifluorom...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(CHEMBL493169 | N-(piperidin-4-yl)-3-(3-(trifluorom...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(CHEMBL493169 | N-(piperidin-4-yl)-3-(3-(trifluorom...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(CHEMBL493169 | N-(piperidin-4-yl)-3-(3-(trifluorom...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(CHEMBL493169 | N-(piperidin-4-yl)-3-(3-(trifluorom...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(CHEMBL493169 | N-(piperidin-4-yl)-3-(3-(trifluorom...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(CHEMBL493169 | N-(piperidin-4-yl)-3-(3-(trifluorom...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(CHEMBL493169 | N-(piperidin-4-yl)-3-(3-(trifluorom...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(CHEMBL493169 | N-(piperidin-4-yl)-3-(3-(trifluorom...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(CHEMBL493169 | N-(piperidin-4-yl)-3-(3-(trifluorom...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(CHEMBL493169 | N-(piperidin-4-yl)-3-(3-(trifluorom...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of PKCtheta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(CHEMBL493169 | N-(piperidin-4-yl)-3-(3-(trifluorom...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of PLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(CHEMBL493169 | N-(piperidin-4-yl)-3-(3-(trifluorom...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50258287(CHEMBL493169 | N-(piperidin-4-yl)-3-(3-(trifluorom...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed