BDBM50258529 CHEMBL449158::bryostatin 1

SMILES CCC/C=C/C=C/C(=O)O[C@H]1/C(=C/C(=O)OC)/C[C@H]2C[C@@H](OC(=O)C[C@@H](C[C@@H]3C[C@@H](C([C@@](O3)(C[C@@H]4C/C(=C/C(=O)OC)/C[C@@H](O4)/C=C/C([C@@]1(O2)O)(C)C)O)(C)C)OC(=O)C)O)[C@@H](C)O

InChI Key InChIKey=MJQUEDHRCUIRLF-UHFFFAOYSA-N

Data  3 KI  5 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50258529   

TargetProtein kinase C epsilon type(Human)
National Cancer Institute-Bethesda

LigandChemical structure of BindingDB Monomer ID 50258529BDBM50258529(CHEMBL449158 | bryostatin 1)
Affinity DataKd:  0.240nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2013
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
National Cancer Institute-Bethesda

LigandChemical structure of BindingDB Monomer ID 50258529BDBM50258529(CHEMBL449158 | bryostatin 1)
Affinity DataKd:  0.260nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2013
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
National Cancer Institute-Bethesda

LigandChemical structure of BindingDB Monomer ID 50258529BDBM50258529(CHEMBL449158 | bryostatin 1)
Affinity DataKd:  0.420nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2013
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
National Cancer Institute-Bethesda

LigandChemical structure of BindingDB Monomer ID 50258529BDBM50258529(CHEMBL449158 | bryostatin 1)
Affinity DataKi:  0.440nMAssay Description:Displacement of [3H]PDBu from human recombinant PKCdelta expressed in Sf9 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein kinase C(Mouse)
National Cancer Institute-Bethesda

LigandChemical structure of BindingDB Monomer ID 50258529BDBM50258529(CHEMBL449158 | bryostatin 1)
Affinity DataKd:  0.480nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2013
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50258529BDBM50258529(CHEMBL449158 | bryostatin 1)
Affinity DataKi:  0.480nMAssay Description:Inhibition of [20-3H]phorbol 12,13-dibutyrate binding to human PKCalpha by scintillation counting based poly(ethylene) glycol precipitation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50258529BDBM50258529(CHEMBL449158 | bryostatin 1)
Affinity DataKd:  0.730nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2013
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
National Cancer Institute-Bethesda

LigandChemical structure of BindingDB Monomer ID 50258529BDBM50258529(CHEMBL449158 | bryostatin 1)
Affinity DataKi:  1.10nMAssay Description:Inhibition of [3H]PDBu binding to recombinant full length human PKCdelta expressed in baculovirus expression system incubated for 5 mins by scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed