BDBM50258975 CHEMBL4094959

SMILES Cn1cc(-c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c2ccccc12

InChI Key InChIKey=KFYRXHYWURCCBT-CQSZACIVSA-N

Data  10 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50258975   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258975(CHEMBL4094959)
Affinity DataIC50:  40nMAssay Description:Inhibition of wild type N-terminal GST-fused human EGFR cytoplasmic domain expressed in baculovirus expression system preincubated for 30 mins follow...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258975(CHEMBL4094959)
Affinity DataIC50:  35nMAssay Description:Inhibition of wild type N-terminal GST-fused human EGFR cytoplasmic domain expressed in baculovirus expression system using TK-substrate after 25 min...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258975(CHEMBL4094959)
Affinity DataIC50:  838nMAssay Description:Inhibition of recombinant human EGFR L858R/T790M/C797S mutant using TK-substrate after 10 mins by HTRF KinEASE-TK assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258975(CHEMBL4094959)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of N-terminal GST-fused human EGFR cytoplasmic domain T790M/C797S mutant expressed in baculovirus expression system using TK-substrate aft...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258975(CHEMBL4094959)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of EGFR T790M/C797S mutant (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258975(CHEMBL4094959)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant GST-tagged EGFR L858R mutant expressed in baculovirus expression system preincubated for 30 mins followed by ATP and ...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258975(CHEMBL4094959)
Affinity DataIC50:  3nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258975(CHEMBL4094959)
Affinity DataIC50:  35nMAssay Description:Inhibition of wild type EGFR (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258975(CHEMBL4094959)
Affinity DataIC50:  58nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Tu Dortmund University

Curated by ChEMBL
LigandPNGBDBM50258975(CHEMBL4094959)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R/T790M double mutant expressed in baculovirus expression system preincubated for 30 mins followe...More data for this Ligand-Target Pair