BDBM50259563 2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1-yl]amino}-2-(3-hydroxyphenyl)acetamide::CHEMBL511410

SMILES: NC(=O)C(Nc1c(Nc2ccncc2)c(=O)c1=O)c1cccc(O)c1

InChI Key: InChIKey=GPXKVULNYYNGDP-UHFFFAOYSA-N

Data: 15 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50259563   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit alpha (Human)	BDBM50259563 (2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C alpha type (Human)	BDBM50259563 (2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Aurora kinase B (Human)	BDBM50259563 (2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Rho-associated protein kinase 1 (Human)	BDBM50259563 (2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase alpha-1 (Human)	BDBM50259563 (2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50259563 (2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM50259563 (2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Casein kinase I isoform gamma-1 (Human)	BDBM50259563 (2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 1 (Human)	BDBM50259563 (2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fyn (Human)	BDBM50259563 (2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 14 (Human)	BDBM50259563 (2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Human)	BDBM50259563 (2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.11E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50259563 (2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM50259563 (2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
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MAP kinase-activated protein kinase 2 (Human)	BDBM50259563 (2-{[3,4-Dioxo-2-(pyridin-4-ylamino)cyclobut-1-en-1...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
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