BDBM50262079 4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline::4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline::CHEMBL513147::LDN-193189

SMILES: c1ccc2c(c1)c(ccn2)c3cnn4c3ncc(c4)c5ccc(cc5)N6CCNCC6

InChI Key: InChIKey=CDOVNWNANFFLFJ-UHFFFAOYSA-N

Data: 49 IC50  4 EC50

PDB links: 4 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 59 hits for monomerid = 50262079   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bone morphogenetic protein 4 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1B (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.65E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1B (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
TGF-beta receptor type-2 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-2A (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-2B (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase receptor R3 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	47	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	48	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1B (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.31E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	810	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1B (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase receptor R3 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1B (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase receptor R3 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-2 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.85E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1B (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.83E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase subunit beta-1 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	565	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
TGF-beta receptor type-2 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase receptor R3 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1B (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1B (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.940	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor protein serine/threonine kinase (Zebrafish)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor protein serine/threonine kinase (Zebrafish)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	40.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	565	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase subunit beta-1/5'-AMP-activated protein kinase subunit gamma-1/Dual specificity protein kinase CLK2 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	215	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase receptor R3 (Mouse)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.48	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1 (Mouse)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.670	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A (Mouse)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14.3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1B (Mouse)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	108	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Mouse)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	117	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1 (Mouse)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor protein serine/threonine kinase (Zebrafish)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	23.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	339	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1B (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1 (Human)	BDBM50262079 (LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	43.3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair