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BDBM50262331 (2-((1H-indazol-6-yl)methylamino)phenyl)(5-chloro-1H-indol-3-yl)methanone::CHEMBL467983

SMILES: Clc1ccc2[nH]cc(C(=O)c3ccccc3NCc3ccc4cn[nH]c4c3)c2c1

InChI Key: InChIKey=LEQPLDOZSPBNOQ-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50262331   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50262331
PNG
((2-((1H-indazol-6-yl)methylamino)phenyl)(5-chloro-...)
Show SMILES Clc1ccc2[nH]cc(C(=O)c3ccccc3NCc3ccc4cn[nH]c4c3)c2c1
Show InChI InChI=1S/C23H17ClN4O/c24-16-7-8-21-18(10-16)19(13-26-21)23(29)17-3-1-2-4-20(17)25-11-14-5-6-15-12-27-28-22(15)9-14/h1-10,12-13,25-26H,11H2,(H,27,28)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 830n/an/an/an/an/an/a



ImClone Systems Inc

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) autophosphorylation by cell based assay


Bioorg Med Chem Lett 18: 4344-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50262331
PNG
((2-((1H-indazol-6-yl)methylamino)phenyl)(5-chloro-...)
Show SMILES Clc1ccc2[nH]cc(C(=O)c3ccccc3NCc3ccc4cn[nH]c4c3)c2c1
Show InChI InChI=1S/C23H17ClN4O/c24-16-7-8-21-18(10-16)19(13-26-21)23(29)17-3-1-2-4-20(17)25-11-14-5-6-15-12-27-28-22(15)9-14/h1-10,12-13,25-26H,11H2,(H,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



ImClone Systems Inc

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) by HTRF assay


Bioorg Med Chem Lett 18: 4344-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.083
BindingDB Entry DOI: 10.7270/Q2542NF0
More data for this
Ligand-Target Pair