BDBM50263192 CHEMBL478858::CHEMBL564483::Pactimibe::[7-(2,2-Dimethylpropanamido)-4,6-dimethyl-1-octylindolin-5-yl]acetic acid

SMILES CCCCCCCCN1CCc2c1c(NC(=O)C(C)(C)C)c(C)c(CC(O)=O)c2C

InChI Key InChIKey=TXIIZHHIOHVWJD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50263192   

TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kyoto Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50263192(CHEMBL478858 | CHEMBL564483 | Pactimibe | [7-(2,2-...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of ACAT-mediated esterified cholesterol accumulation in human THP1 cells exposed to acetyl-LDL during differentiation assessed as effect o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kyoto Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50263192(CHEMBL478858 | CHEMBL564483 | Pactimibe | [7-(2,2-...)
Affinity DataIC50:  300nMAssay Description:Inhibition of ACAT-mediated esterified cholesterol accumulation in human THP1 cells exposed to acetyl-LDL after differentiation assessed as effect on...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kyoto Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50263192(CHEMBL478858 | CHEMBL564483 | Pactimibe | [7-(2,2-...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of ACAT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 2(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50263192(CHEMBL478858 | CHEMBL564483 | Pactimibe | [7-(2,2-...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of macrophage ACAT2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
Kyoto Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50263192(CHEMBL478858 | CHEMBL564483 | Pactimibe | [7-(2,2-...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of ACAT in Japanese White rabbit liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed