BDBM50263192 CHEMBL478858::CHEMBL564483::Pactimibe::[7-(2,2-Dimethylpropanamido)-4,6-dimethyl-1-octylindolin-5-yl]acetic acid
SMILES CCCCCCCCN1CCc2c1c(NC(=O)C(C)(C)C)c(C)c(CC(O)=O)c2C
InChI Key InChIKey=TXIIZHHIOHVWJD-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50263192
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kyoto Pharmaceutical Industries
Curated by ChEMBL
Kyoto Pharmaceutical Industries
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of ACAT-mediated esterified cholesterol accumulation in human THP1 cells exposed to acetyl-LDL during differentiation assessed as effect o...More data for this Ligand-Target Pair
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kyoto Pharmaceutical Industries
Curated by ChEMBL
Kyoto Pharmaceutical Industries
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of ACAT-mediated esterified cholesterol accumulation in human THP1 cells exposed to acetyl-LDL after differentiation assessed as effect on...More data for this Ligand-Target Pair
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Kyoto Pharmaceutical Industries
Curated by ChEMBL
Kyoto Pharmaceutical Industries
Curated by ChEMBL
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of ACAT1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of macrophage ACAT2 (unknown origin)More data for this Ligand-Target Pair
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
Kyoto Pharmaceutical Industries
Curated by ChEMBL
Kyoto Pharmaceutical Industries
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of ACAT in Japanese White rabbit liver microsomesMore data for this Ligand-Target Pair