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BDBM50263334 9-(4-fluoro-3-methylphenyl)-2-hydroxy-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid::CHEMBL477381

InChI string: InChI=1S/C24H18FNO3/c1-12-8-13(4-7-20(12)25)14-2-5-16-17-6-3-15-9-19(24(28)29)22(27)11-18(15)23(17)26-21(16)10-14/h2,4-5,7-11,26-27H,3,6H2,1H3,(H,28,29)

SMILES: Cc1cc(ccc1F)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1

InChI Key: InChIKey=ARVZEAPYEMTUPV-UHFFFAOYSA-N

Data: 1 EC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50263334   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50263334
PNG
(9-(4-fluoro-3-methylphenyl)-2-hydroxy-6,11-dihydro...)
Show SMILES Cc1cc(ccc1F)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C24H18FNO3/c1-12-8-13(4-7-20(12)25)14-2-5-16-17-6-3-15-9-19(24(28)29)22(27)11-18(15)23(17)26-21(16)10-14/h2,4-5,7-11,26-27H,3,6H2,1H3,(H,28,29)
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AffyNet 
Article
PubMed
n/an/an/an/a 35n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Bioorg Med Chem Lett 18: 5255-8 (2008)

More data for this
Ligand-Target Pair