BindingDB logo
myBDB logout

BDBM50263892 6-Fluoro-1-[1'-(2-methyl-benzyl)-[1,4']bipiperidinyl-4-yl]-1,3-dihydro-benzoimidazol-2-one::CHEMBL490797

SMILES: Cc1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O

InChI Key: InChIKey=IVSZXUDAZZHELN-UHFFFAOYSA-N

Data: 1 IC50  5 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50263892   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M1/M5 chimeric protein


(Homo sapiens (Human))
BDBM50263892
PNG
(6-Fluoro-1-[1'-(2-methyl-benzyl)-[1,4']bipiperidin...)
Show SMILES Cc1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O
Show InChI InChI=1S/C25H31FN4O/c1-18-4-2-3-5-19(18)17-28-12-8-21(9-13-28)29-14-10-22(11-15-29)30-24-16-20(26)6-7-23(24)27-25(30)31/h2-7,16,21-22H,8-15,17H2,1H3,(H,27,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>5.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M5 receptor (unknown origin)


Bioorg Med Chem Lett 18: 5439-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.023
BindingDB Entry DOI: 10.7270/Q2708198
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50263892
PNG
(6-Fluoro-1-[1'-(2-methyl-benzyl)-[1,4']bipiperidin...)
Show SMILES Cc1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O
Show InChI InChI=1S/C25H31FN4O/c1-18-4-2-3-5-19(18)17-28-12-8-21(9-13-28)29-14-10-22(11-15-29)30-24-16-20(26)6-7-23(24)27-25(30)31/h2-7,16,21-22H,8-15,17H2,1H3,(H,27,31)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.760n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M1 receptor (unknown origin)


Bioorg Med Chem Lett 18: 5439-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.023
BindingDB Entry DOI: 10.7270/Q2708198
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50263892
PNG
(6-Fluoro-1-[1'-(2-methyl-benzyl)-[1,4']bipiperidin...)
Show SMILES Cc1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O
Show InChI InChI=1S/C25H31FN4O/c1-18-4-2-3-5-19(18)17-28-12-8-21(9-13-28)29-14-10-22(11-15-29)30-24-16-20(26)6-7-23(24)27-25(30)31/h2-7,16,21-22H,8-15,17H2,1H3,(H,27,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of dopamine D2 receptor (unknown origin)


Bioorg Med Chem Lett 18: 5439-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.023
BindingDB Entry DOI: 10.7270/Q2708198
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50263892
PNG
(6-Fluoro-1-[1'-(2-methyl-benzyl)-[1,4']bipiperidin...)
Show SMILES Cc1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O
Show InChI InChI=1S/C25H31FN4O/c1-18-4-2-3-5-19(18)17-28-12-8-21(9-13-28)29-14-10-22(11-15-29)30-24-16-20(26)6-7-23(24)27-25(30)31/h2-7,16,21-22H,8-15,17H2,1H3,(H,27,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>5.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M3 receptor (unknown origin)


Bioorg Med Chem Lett 18: 5439-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.023
BindingDB Entry DOI: 10.7270/Q2708198
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM50263892
PNG
(6-Fluoro-1-[1'-(2-methyl-benzyl)-[1,4']bipiperidin...)
Show SMILES Cc1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O
Show InChI InChI=1S/C25H31FN4O/c1-18-4-2-3-5-19(18)17-28-12-8-21(9-13-28)29-14-10-22(11-15-29)30-24-16-20(26)6-7-23(24)27-25(30)31/h2-7,16,21-22H,8-15,17H2,1H3,(H,27,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>5.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M4 receptor (unknown origin)


Bioorg Med Chem Lett 18: 5439-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.023
BindingDB Entry DOI: 10.7270/Q2708198
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50263892
PNG
(6-Fluoro-1-[1'-(2-methyl-benzyl)-[1,4']bipiperidin...)
Show SMILES Cc1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O
Show InChI InChI=1S/C25H31FN4O/c1-18-4-2-3-5-19(18)17-28-12-8-21(9-13-28)29-14-10-22(11-15-29)30-24-16-20(26)6-7-23(24)27-25(30)31/h2-7,16,21-22H,8-15,17H2,1H3,(H,27,31)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>5.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M2 receptor (unknown origin)


Bioorg Med Chem Lett 18: 5439-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.023
BindingDB Entry DOI: 10.7270/Q2708198
More data for this
Ligand-Target Pair