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BDBM50264951 6-fluoro-7-(4-propylphenyl)-5,10-dihydroindeno[1,2-b]indole-2-carboxylic acid::CHEMBL496122

InChI string: InChI=1S/C25H20FNO2/c1-2-3-14-4-6-15(7-5-14)18-10-11-20-21-13-17-12-16(25(28)29)8-9-19(17)23(21)27-24(20)22(18)26/h4-12,27H,2-3,13H2,1H3,(H,28,29)

SMILES: CCCc1ccc(cc1)-c1ccc2c3Cc4cc(ccc4-c3[nH]c2c1F)C(O)=O

InChI Key: InChIKey=UPXVSLNEPJUZQB-UHFFFAOYSA-N

Data: 1 EC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50264951   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50264951
PNG
(6-fluoro-7-(4-propylphenyl)-5,10-dihydroindeno[1,2...)
Show SMILES CCCc1ccc(cc1)-c1ccc2c3Cc4cc(ccc4-c3[nH]c2c1F)C(O)=O
Show InChI InChI=1S/C25H20FNO2/c1-2-3-14-4-6-15(7-5-14)18-10-11-20-21-13-17-12-16(25(28)29)8-9-19(17)23(21)27-24(20)22(18)26/h4-12,27H,2-3,13H2,1H3,(H,28,29)
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PC sid
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Similars

AffyNet 
Article
PubMed
n/an/an/an/a 37n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assay


Bioorg Med Chem Lett 18: 5259-62 (2008)

More data for this
Ligand-Target Pair