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BDBM50264952 6-fluoro-7-(4-fluoro-3-methylphenyl)-5,10-dihydroindeno[1,2-b]indole-2-carboxylic acid::CHEMBL496123

InChI string: InChI=1S/C23H15F2NO2/c1-11-8-12(3-7-19(11)24)15-5-6-17-18-10-14-9-13(23(27)28)2-4-16(14)21(18)26-22(17)20(15)25/h2-9,26H,10H2,1H3,(H,27,28)

SMILES: Cc1cc(ccc1F)-c1ccc2c3Cc4cc(ccc4-c3[nH]c2c1F)C(O)=O

InChI Key: InChIKey=XUKQPLWMMZKKRI-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50264952   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50264952
PNG
(6-fluoro-7-(4-fluoro-3-methylphenyl)-5,10-dihydroi...)
Show SMILES Cc1cc(ccc1F)-c1ccc2c3Cc4cc(ccc4-c3[nH]c2c1F)C(O)=O
Show InChI InChI=1S/C23H15F2NO2/c1-11-8-12(3-7-19(11)24)15-5-6-17-18-10-14-9-13(23(27)28)2-4-16(14)21(18)26-22(17)20(15)25/h2-9,26H,10H2,1H3,(H,27,28)
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AffyNet 
Article
PubMed
n/an/an/an/a 26n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assay


Bioorg Med Chem Lett 18: 5259-62 (2008)

More data for this
Ligand-Target Pair