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BDBM50265150 2-(7-(4-butylphenyl)-6-fluoro-5,10-dihydroindeno[1,2-b]indol-2-ylamino)-2-oxoacetic acid::CHEMBL498173

InChI string: InChI=1S/C27H23FN2O3/c1-2-3-4-15-5-7-16(8-6-15)19-11-12-21-22-14-17-13-18(29-26(31)27(32)33)9-10-20(17)24(22)30-25(21)23(19)28/h5-13,30H,2-4,14H2,1H3,(H,29,31)(H,32,33)

SMILES: CCCCc1ccc(cc1)-c1ccc2c3Cc4cc(NC(=O)C(O)=O)ccc4-c3[nH]c2c1F

InChI Key: InChIKey=KBHMPAXRTWKCOT-UHFFFAOYSA-N

Data: 1 EC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50265150   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50265150
PNG
(2-(7-(4-butylphenyl)-6-fluoro-5,10-dihydroindeno[1...)
Show SMILES CCCCc1ccc(cc1)-c1ccc2c3Cc4cc(NC(=O)C(O)=O)ccc4-c3[nH]c2c1F
Show InChI InChI=1S/C27H23FN2O3/c1-2-3-4-15-5-7-16(8-6-15)19-11-12-21-22-14-17-13-18(29-26(31)27(32)33)9-10-20(17)24(22)30-25(21)23(19)28/h5-13,30H,2-4,14H2,1H3,(H,29,31)(H,32,33)
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AffyNet 
Article
PubMed
n/an/an/an/a 21n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair