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BDBM50265581 CHEMBL505036::N-{1-[1-(Morpholin-4-ylcarbonyl)-L-prolyl]piperidin-4-yl}-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide

SMILES: FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)N1CCOCC1)S(=O)(=O)c1ccccc1

InChI Key: InChIKey=RIBOGOWWMKNBLE-FQKVKQEKNA-N

Data: 1 IC50  1 EC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50265581   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Secreted frizzled-related protein 1


(Homo sapiens (Human))
BDBM50265581
PNG
(CHEMBL505036 | N-{1-[1-(Morpholin-4-ylcarbonyl)-L-...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)N1CCOCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1/C28H33F3N4O7S2/c29-28(30,31)23-9-8-22(43(38,39)21-5-2-1-3-6-21)19-25(23)44(40,41)32-20-10-13-33(14-11-20)26(36)24-7-4-12-35(24)27(37)34-15-17-42-18-16-34/h1-3,5-6,8-9,19-20,24,32H,4,7,10-18H2/t24-/s2
NCI pathway
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UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 40n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity to human purified SARP2 by fluorescent polarization assay


J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair
Proto-oncogene protein Wnt-3


(Homo sapiens (Human))
BDBM50265581
PNG
(CHEMBL505036 | N-{1-[1-(Morpholin-4-ylcarbonyl)-L-...)
Show SMILES FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)N1CCOCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1/C28H33F3N4O7S2/c29-28(30,31)23-9-8-22(43(38,39)21-5-2-1-3-6-21)19-25(23)44(40,41)32-20-10-13-33(14-11-20)26(36)24-7-4-12-35(24)27(37)34-15-17-42-18-16-34/h1-3,5-6,8-9,19-20,24,32H,4,7,10-18H2/t24-/s2
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 280n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assay


J Med Chem 52: 105-16 (2009)


Article DOI: 10.1021/jm801144h
BindingDB Entry DOI: 10.7270/Q2NZ87HT
More data for this
Ligand-Target Pair