BDBM50265660 CHEMBL4091093

SMILES CN1C=C(C(=CC1=O)OC)c2cc(ccc2Oc3ccccc3)NS(=O)(=O)C

InChI Key InChIKey=RHNWTJMCFPHSQX-UHFFFAOYSA-N

Data  1 KI  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50265660   

TargetBromodomain-containing protein 4(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50265660(CHEMBL4091093)
Affinity DataKi:  58nMAssay Description:Inhibition of human N-terminal His6-tagged BRD4 BD1-BD2 (57 to 550 residues) expressed in EScherichia coli BL21(DE3) after 1 hr by Alexa-647-conjugat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50265660(CHEMBL4091093)
Affinity DataEC50:  77nMAssay Description:Inhibition of BRD4 in human NCI-H1299 cells after 24 hrs by Bright-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2020
Entry Details Article
PubMed