BDBM50265795 CHEMBL3736000

SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1ccc(F)c(F)c1)C(=O)c1ccccn1

InChI Key InChIKey=GJEYPXYKCVXQTL-NDEPHWFRSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50265795   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50265795(CHEMBL3736000)
Affinity DataKi:  0.220nMAssay Description:Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50265795(CHEMBL3736000)
Affinity DataKi:  0.220nMAssay Description:Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50265795(CHEMBL3736000)
Affinity DataKi:  7.5nMAssay Description:Antagonist activity at glucocorticoid receptor in human HepG2 cells assessed as inhibition of glucocorticoid-induced TAT activity after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50265795(CHEMBL3736000)
Affinity DataKi:  7.5nMAssay Description:Antagonist activity at glucocorticoid receptor in human HepG2 cells assessed as inhibition of dexamethasone-induced tyrosine amino transferase activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed