BDBM50266148 CHEMBL465793::N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amine

SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nc3ccccc3[nH]2)c2ccccc12

InChI Key InChIKey=GGIPEVUWPMVPNG-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50266148   

TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266148(CHEMBL465793 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Tie2 autophosphorylation in human Ea.hy926 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266148(CHEMBL465793 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266148(CHEMBL465793 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266148(CHEMBL465793 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Tie2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266148(CHEMBL465793 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266148(CHEMBL465793 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  19nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266148(CHEMBL465793 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  19nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266148(CHEMBL465793 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  1.38E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266148(CHEMBL465793 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  292nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266148(CHEMBL465793 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed