BDBM50266185 CHEMBL463323::N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine::N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine::N-[4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)naphthalen-1-yl]-6-(trifluoromethyl)-1H-benzimidazol-2-amine

SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nc3ccc(cc3[nH]2)C(F)(F)F)c2ccccc12

InChI Key InChIKey=VIHXUAKPZPXVSW-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50266185   

TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266185(CHEMBL463323 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  56nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266185(CHEMBL463323 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  27nMAssay Description:Inhibition of Tie2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266185(CHEMBL463323 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  69nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266185(CHEMBL463323 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  27nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266185(CHEMBL463323 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  70nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266185(CHEMBL463323 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  132nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266185(CHEMBL463323 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  16nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed