BDBM50267487 1-(4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfonyl)piperazin-1-yl)-2-(4-(trifluoromethyl)phenyl)ethanone::CHEMBL516900

SMILES FC(F)(F)c1ccc(CC(=O)N2CCN(CC2)S(=O)(=O)c2cc(cc(c2)C(F)(F)F)C2CC2)cc1

InChI Key InChIKey=DVPAFQJRBKXLSG-UHFFFAOYSA-N

Data  6 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50267487   

TargetCannabinoid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267487(1-(4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]CP55940 from human recombinant CB2R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267487(1-(4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfo...)
Affinity DataIC50:  1.90nMAssay Description:Antagonist activity at rat recombinant CB1R expressed in CHO cells assessed as inhibition of methanandamide-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267487(1-(4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfo...)
Affinity DataIC50:  27nMAssay Description:Displacement of [3H]CP55940 from rat recombinant CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267487(1-(4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfo...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [3H]SR141716 from human recombinant CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267487(1-(4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfo...)
Affinity DataEC50:  1nMAssay Description:Inverse agonist activity at human recombinant CB1R expressed in CHO cells assessed as increase in forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267487(1-(4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfo...)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human recombinant CB1R expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267487(1-(4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfo...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at rat recombinant CB1R expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267487(1-(4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfo...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]CP55940 from human recombinant CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50267487(1-(4-(3-cyclopropyl-5-(trifluoromethyl)phenylsulfo...)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H] SR141716 from rat recombinant CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed