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BDBM50267816 4-{[2-(3,4-Dihydroxy-phenyl)-ethylamino]-methylene}-4H-isoquinoline-1,3-dione::CHEMBL489431

SMILES: Oc1ccc(CCNC=C2C(=O)NC(=O)c3ccccc23)cc1O

InChI Key: InChIKey=YGRPGFBUNPPGAB-UVTDQMKNSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50267816   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM50267816
PNG
(4-{[2-(3,4-Dihydroxy-phenyl)-ethylamino]-methylene...)
Show SMILES Oc1ccc(CCNC=C2C(=O)NC(=O)c3ccccc23)cc1O
Show InChI InChI=1S/C18H16N2O4/c21-15-6-5-11(9-16(15)22)7-8-19-10-14-12-3-1-2-4-13(12)17(23)20-18(14)24/h1-6,9-10,19,21-22H,7-8H2,(H,20,23,24)/b14-10-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.62E+4n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylation


J Med Chem 52: 2289-310 (2009)


Article DOI: 10.1021/jm801026e
BindingDB Entry DOI: 10.7270/Q27H1JG7
More data for this
Ligand-Target Pair