BDBM50267856 CHEMBL4063870
SMILES C[C@]1(N)CC[C@@H](Nc2c(cnn3cc(cc23)-c2ccncc2)C(N)=O)C1(C)C
InChI Key InChIKey=HQTPPNMZPPOXES-UTKZUKDTSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50267856
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataIC50: 6.70nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataIC50: 4.90nMAssay Description:Inhibition of GST-tagged JAK1 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of human ERG by flux-based assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of GST-tagged JAK2 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of JAK1/JAK3 in human whole blood assessed as reduction in IL-2 induced IFN-gamma production after 18 hrs by ELISAMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of His-tagged TYK2 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair