BDBM50268453 (5-(1-isopropylpiperidin-4-yloxy)-2-methyl-1H-indol-3-yl)(morpholino)methanone::CHEMBL496814

SMILES: CC(C)N1CCC(CC1)Oc1ccc2[nH]c(C)c(C(=O)N3CCOCC3)c2c1

InChI Key: InChIKey=QGXYCOWWFZBLQY-UHFFFAOYSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50268453   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50268453 ((5-(1-isopropylpiperidin-4-yloxy)-2-methyl-1H-indo...) Show SMILES CC(C)N1CCC(CC1)Oc1ccc2[nH]c(C)c(C(=O)N3CCOCC3)c2c1 Show InChI InChI=1S/C22H31N3O3/c1-15(2)24-8-6-17(7-9-24)28-18-4-5-20-19(14-18)21(16(3)23-20)22(26)25-10-12-27-13-11-25/h4-5,14-15,17,23H,6-13H2,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	86	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Inc Curated by ChEMBL					Assay Description Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting				J Med Chem 52: 3855-68 (2009) Article DOI: 10.1021/jm900409x BindingDB Entry DOI: 10.7270/Q2SB46NQ
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50268453 ((5-(1-isopropylpiperidin-4-yloxy)-2-methyl-1H-indo...) Show SMILES CC(C)N1CCC(CC1)Oc1ccc2[nH]c(C)c(C(=O)N3CCOCC3)c2c1 Show InChI InChI=1S/C22H31N3O3/c1-15(2)24-8-6-17(7-9-24)28-18-4-5-20-19(14-18)21(16(3)23-20)22(26)25-10-12-27-13-11-25/h4-5,14-15,17,23H,6-13H2,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	405	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Inc Curated by ChEMBL					Assay Description Inverse agonist activity at human histamine H3 receptor expressed in CHO cells by GTPgamma[35S] binding assay				J Med Chem 52: 3855-68 (2009) Article DOI: 10.1021/jm900409x BindingDB Entry DOI: 10.7270/Q2SB46NQ
					More data for this Ligand-Target Pair