BDBM50269948 6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one::CHEMBL514554::D3RKN_2::PF-228::US10266549, Example 32::US10774092, Example 32

SMILES: CS(=O)(=O)c1cccc(c1)CNc2c(cnc(n2)Nc3ccc4c(c3)CCC(=O)N4)C(F)(F)F

InChI Key: InChIKey=HESLKTSGTIBHJU-UHFFFAOYSA-N

Data: 20 IC50  3 Kd

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50269948   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase ULK1 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Focal adhesion kinase 1 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 7 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	197	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 1 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	486	n/a	n/a	n/a	n/a	n/a	n/a
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Protein-tyrosine kinase 2-beta (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Focal adhesion kinase 1 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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Focal adhesion kinase 1 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
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Focal adhesion kinase 1 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
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Focal adhesion kinase 1 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
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Focal adhesion kinase 1 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
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Focal adhesion kinase 1 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Protein-tyrosine kinase 2-beta (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a
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Focal adhesion kinase 1 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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Focal adhesion kinase 1 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Protein-tyrosine kinase 2-beta (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 14 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK2 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase ULK1 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Protein-tyrosine kinase 2-beta (Human)	BDBM50269948 (PF-228 | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(t...) Show SMILES Show InChI	GoogleScholar	UniChem		3.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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