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BDBM50270075 CHEMBL504546::TPAERRRKKRV

SMILES: [#6]-[#6](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@@H](-[#7])-[#6@@H](-[#6])-[#8])-[#6](-[#8])=O

InChI Key: InChIKey=PCGVAFRUJKWALY-KDOAHFMINA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50270075   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50270075
PNG
(CHEMBL504546 | TPAERRRKKRV)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)C(O)=O
Show InChI InChI=1/C58H109N25O15/c1-30(2)43(54(97)98)82-51(94)38(19-12-28-73-58(68)69)81-46(89)34(15-6-8-24-60)76-45(88)33(14-5-7-23-59)77-47(90)35(16-9-25-70-55(62)63)78-48(91)36(17-10-26-71-56(64)65)79-49(92)37(18-11-27-72-57(66)67)80-50(93)39(21-22-41(85)86)75-44(87)31(3)74-52(95)40-20-13-29-83(40)53(96)42(61)32(4)84/h30-40,42-43,84H,5-29,59-61H2,1-4H3,(H,74,95)(H,75,87)(H,76,88)(H,77,90)(H,78,91)(H,79,92)(H,80,93)(H,81,89)(H,82,94)(H,85,86)(H,97,98)(H4,62,63,70)(H4,64,65,71)(H4,66,67,72)(H4,68,69,73)/t31-,32+,33-,34-,35-,36-,37-,38-,39-,40-,42-,43-/s2
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>100n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair