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BDBM50270806 CHEMBL527054::QRFCTGHFGGAYPCNGP

SMILES: C[C@@H](O)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCC(N)=O)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(O)=O

InChI Key: InChIKey=WWJNRJDIESOSSX-NYKNEHNGNA-N

Data: 1 IC50  1 Kd

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50270806   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
IgG receptor FcRn large subunit p51


(Homo sapiens (Human))
BDBM50270806
PNG
(CHEMBL527054 | QRFCTGHFGGAYPCNGP)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCC(N)=O)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(O)=O
Show InChI InChI=1/C79H110N24O22S2/c1-41(66(112)98-54(30-45-19-21-47(105)22-20-45)77(123)103-27-10-17-57(103)75(121)100-55(38-126)73(119)97-53(32-60(82)107)69(115)90-37-64(111)102-26-11-18-58(102)78(124)125)92-62(109)35-87-61(108)34-88-68(114)50(28-43-12-5-3-6-13-43)95-72(118)52(31-46-33-85-40-91-46)93-63(110)36-89-76(122)65(42(2)104)101-74(120)56(39-127)99-71(117)51(29-44-14-7-4-8-15-44)96-70(116)49(16-9-25-86-79(83)84)94-67(113)48(80)23-24-59(81)106/h3-8,12-15,19-22,33,40-42,48-58,65,104-105,126-127H,9-11,16-18,23-32,34-39,80H2,1-2H3,(H2,81,106)(H2,82,107)(H,85,91)(H,87,108)(H,88,114)(H,89,122)(H,90,115)(H,92,109)(H,93,110)(H,94,113)(H,95,118)(H,96,116)(H,97,119)(H,98,112)(H,99,117)(H,100,121)(H,101,120)(H,124,125)(H4,83,84,86)/t41-,42+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,65-/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 2.60E+4n/an/an/a6.0n/a



Syntonix Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human FcRn at pH 6 by surface plasmon resonance assay


Bioorg Med Chem 16: 6394-405 (2008)


Article DOI: 10.1016/j.bmc.2008.05.004
BindingDB Entry DOI: 10.7270/Q2QV3M9C
More data for this
Ligand-Target Pair
IgG receptor FcRn large subunit p51


(Homo sapiens (Human))
BDBM50270806
PNG
(CHEMBL527054 | QRFCTGHFGGAYPCNGP)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCC(N)=O)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(O)=O
Show InChI InChI=1/C79H110N24O22S2/c1-41(66(112)98-54(30-45-19-21-47(105)22-20-45)77(123)103-27-10-17-57(103)75(121)100-55(38-126)73(119)97-53(32-60(82)107)69(115)90-37-64(111)102-26-11-18-58(102)78(124)125)92-62(109)35-87-61(108)34-88-68(114)50(28-43-12-5-3-6-13-43)95-72(118)52(31-46-33-85-40-91-46)93-63(110)36-89-76(122)65(42(2)104)101-74(120)56(39-127)99-71(117)51(29-44-14-7-4-8-15-44)96-70(116)49(16-9-25-86-79(83)84)94-67(113)48(80)23-24-59(81)106/h3-8,12-15,19-22,33,40-42,48-58,65,104-105,126-127H,9-11,16-18,23-32,34-39,80H2,1-2H3,(H2,81,106)(H2,82,107)(H,85,91)(H,87,108)(H,88,114)(H,89,122)(H,90,115)(H,92,109)(H,93,110)(H,94,113)(H,95,118)(H,96,116)(H,97,119)(H,98,112)(H,99,117)(H,100,121)(H,101,120)(H,124,125)(H4,83,84,86)/t41-,42+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,65-/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.07E+5n/an/an/an/an/an/a



Syntonix Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IgG binding to soluble human FcRn by ELISA


Bioorg Med Chem 16: 6394-405 (2008)


Article DOI: 10.1016/j.bmc.2008.05.004
BindingDB Entry DOI: 10.7270/Q2QV3M9C
More data for this
Ligand-Target Pair