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BDBM50270984 (2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{2-[(2S)-2-[(2S)-2-{2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-5-carbamimidamidopentanamido]-3-phenylpropanamido]-3-methylbutanamido]-3-hydroxybutanamido]acetamido}-3-(1H-imidazol-5-yl)propanamido]-3-phenylpropanamido]-N-methylacetamido}-N-methylacetamido)-4-methylpentanamido]-3-(4-hydroxyphenyl)propanoyl]pyrrolidin-2-yl]formamido}propanoic acid::CHEMBL499121

SMILES: CC(C)C[C@H](N(C)C(=O)CN(C)C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCCN=C(N)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O

InChI Key: InChIKey=GBPJUAXDJHWEIX-QCRZSQONSA-N

Data: 1 IC50  1 Kd

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50270984   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
IgG receptor FcRn large subunit p51


(Homo sapiens)
BDBM50270984
PNG
((2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{2-[(2S)-2-[(2S...)
Show SMILES CC(C)C[C@H](N(C)C(=O)CN(C)C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCCN=C(N)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O
Show InChI InChI=1S/C70H100N18O16/c1-39(2)29-54(65(99)83-52(32-45-23-25-47(90)26-24-45)68(102)88-28-16-22-53(88)64(98)79-41(5)69(103)104)87(8)57(93)37-86(7)56(92)36-77-61(95)49(30-43-17-11-9-12-18-43)82-62(96)51(33-46-34-74-38-78-46)80-55(91)35-76-66(100)59(42(6)89)85-67(101)58(40(3)4)84-63(97)50(31-44-19-13-10-14-20-44)81-60(94)48(71)21-15-27-75-70(72)73/h9-14,17-20,23-26,34,38-42,48-54,58-59,89-90H,15-16,21-22,27-33,35-37,71H2,1-8H3,(H,74,78)(H,76,100)(H,77,95)(H,79,98)(H,80,91)(H,81,94)(H,82,96)(H,83,99)(H,84,97)(H,85,101)(H,103,104)(H4,72,73,75)/t41-,42+,48-,49-,50-,51-,52-,53-,54-,58-,59-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.70E+4n/an/an/an/an/an/a



Syntonix Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IgG binding to soluble human FcRn by ELISA


Bioorg Med Chem 16: 6394-405 (2008)


Article DOI: 10.1016/j.bmc.2008.05.004
BindingDB Entry DOI: 10.7270/Q2QV3M9C
More data for this
Ligand-Target Pair
IgG receptor FcRn large subunit p51


(Homo sapiens)
BDBM50270984
PNG
((2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{2-[(2S)-2-[(2S...)
Show SMILES CC(C)C[C@H](N(C)C(=O)CN(C)C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCCN=C(N)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O
Show InChI InChI=1S/C70H100N18O16/c1-39(2)29-54(65(99)83-52(32-45-23-25-47(90)26-24-45)68(102)88-28-16-22-53(88)64(98)79-41(5)69(103)104)87(8)57(93)37-86(7)56(92)36-77-61(95)49(30-43-17-11-9-12-18-43)82-62(96)51(33-46-34-74-38-78-46)80-55(91)35-76-66(100)59(42(6)89)85-67(101)58(40(3)4)84-63(97)50(31-44-19-13-10-14-20-44)81-60(94)48(71)21-15-27-75-70(72)73/h9-14,17-20,23-26,34,38-42,48-54,58-59,89-90H,15-16,21-22,27-33,35-37,71H2,1-8H3,(H,74,78)(H,76,100)(H,77,95)(H,79,98)(H,80,91)(H,81,94)(H,82,96)(H,83,99)(H,84,97)(H,85,101)(H,103,104)(H4,72,73,75)/t41-,42+,48-,49-,50-,51-,52-,53-,54-,58-,59-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 1.85E+3n/an/an/an/an/a



Syntonix Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human FcRn at pH 6 by surface plasmon resonance assay


Bioorg Med Chem 16: 6394-405 (2008)


Article DOI: 10.1016/j.bmc.2008.05.004
BindingDB Entry DOI: 10.7270/Q2QV3M9C
More data for this
Ligand-Target Pair