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BDBM50271840 6-Methyl-7-(3-morpholinopropoxy)-4-(benzothiazol-2-ylamino)-quinoline-3-carbonitrile::CHEMBL484311

SMILES: Cc1cc2c(Nc3nc4ccccc4s3)c(cnc2cc1OCCCN1CCOCC1)C#N

InChI Key: InChIKey=ZUWINFKFSSETPQ-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50271840   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nitric Oxide Synthase, inducible


(Mus musculus (mouse))
BDBM50271840
PNG
(6-Methyl-7-(3-morpholinopropoxy)-4-(benzothiazol-2...)
Show SMILES Cc1cc2c(Nc3nc4ccccc4s3)c(cnc2cc1OCCCN1CCOCC1)C#N
Show InChI InChI=1S/C25H25N5O2S/c1-17-13-19-21(14-22(17)32-10-4-7-30-8-11-31-12-9-30)27-16-18(15-26)24(19)29-25-28-20-5-2-3-6-23(20)33-25/h2-3,5-6,13-14,16H,4,7-12H2,1H3,(H,27,28,29)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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DrugBank
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.39E+5n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of inducible nitric oxide synthetase in LPS-stimulated mouse ANA1 macrophages


Bioorg Med Chem 16: 5890-8 (2008)


Article DOI: 10.1016/j.bmc.2008.04.065
BindingDB Entry DOI: 10.7270/Q2Z60PZ6
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50271840
PNG
(6-Methyl-7-(3-morpholinopropoxy)-4-(benzothiazol-2...)
Show SMILES Cc1cc2c(Nc3nc4ccccc4s3)c(cnc2cc1OCCCN1CCOCC1)C#N
Show InChI InChI=1S/C25H25N5O2S/c1-17-13-19-21(14-22(17)32-10-4-7-30-8-11-31-12-9-30)27-16-18(15-26)24(19)29-25-28-20-5-2-3-6-23(20)33-25/h2-3,5-6,13-14,16H,4,7-12H2,1H3,(H,27,28,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 172n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cSrc by ELISA


Bioorg Med Chem 16: 5890-8 (2008)


Article DOI: 10.1016/j.bmc.2008.04.065
BindingDB Entry DOI: 10.7270/Q2Z60PZ6
More data for this
Ligand-Target Pair