BDBM50273219 2-Cyano-4-[(spiro[2.5]oct-6-ylmethyl)-amino]-pyrimidine-5-carboxylic acid (4,5-dimethoxy-biphenyl-2-yl)-amide::CHEMBL456757

SMILES COc1cc(NC(=O)c2cnc(nc2NCC2CCC3(CC3)CC2)C#N)c(cc1OC)-c1ccccc1

InChI Key InChIKey=YIUAAJTVPXTPNW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50273219   

TargetProcathepsin L(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273219(2-Cyano-4-[(spiro[2.5]oct-6-ylmethyl)-amino]-pyrim...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of human recombinant cathepsin L by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273219(2-Cyano-4-[(spiro[2.5]oct-6-ylmethyl)-amino]-pyrim...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human recombinant cathepsin S by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273219(2-Cyano-4-[(spiro[2.5]oct-6-ylmethyl)-amino]-pyrim...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human recombinant cathepsin K by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed