BDBM50273858 2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(1-hydroxycyclobutyl)-5-methylthiazol-4(5H)-one::CHEMBL460393

SMILES C[C@H](NC1=NC(=O)C(C)(S1)C1(O)CCC1)c1ccc(F)cc1

InChI Key InChIKey=ITBTWAJBZMDXOD-MYHCZTBNSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50273858   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50273858(2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(1-hydroxyc...)
Affinity DataKi:  49nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50273858(2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(1-hydroxyc...)
Affinity DataIC50:  32nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50273858(2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(1-hydroxyc...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO cells using [3H]cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed