BDBM50274482 (2E)-N-[(5R,6R)-17-(Cyclopropylmethyl)-4,5-epoxy-14-hydroxymorphinan-6-yl]-3-(furan-3-yl)-N-methylprop-2-enamide::CHEMBL485583
SMILES CN([C@@H]1CC[C@@]2(O)[C@H]3Cc4cccc5O[C@@H]1[C@]2(CCN3CC1CC1)c45)C(=O)\C=C\c1ccoc1
InChI Key InChIKey=XNAXOXVMRWBOSY-YDLVXVFUSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50274482
Affinity DataKi: 0.130nMAssay Description:Displacement of [3H]-U-69593 from recombinant human KOR expressed in CHO cell membranes measured after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]-DAMGO from recombinant human MOR expressed in CHO cell membranes measured after 2 hrs by microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Kitasato University
Curated by ChEMBL
Kitasato University
Curated by ChEMBL
Affinity DataKi: 2.82nMAssay Description:Displacement of [3H]U-69,593 from kappa opioid receptor in guinea pig cerebellumMore data for this Ligand-Target Pair
Affinity DataKi: 169nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in mouse cerebellumMore data for this Ligand-Target Pair
Affinity DataKi: 408nMAssay Description:Displacement of [3H]-DPDPE from recombinant human DOR expressed in CHO cell membranes measured after 2 hrs by microbeta scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in mouse cerebellumMore data for this Ligand-Target Pair
Affinity DataKi: 1.25E+3nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
Affinity DataIC50: 27.2nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair