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BDBM50275241 (Z)-6-Methyl-1-((5-phenylfuran-2-yl)methylene)-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-one::CHEMBL486580

SMILES: Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1ccc(o1)-c1ccccc1

InChI Key: InChIKey=BYYVTPCGYPACOV-YBEGLDIGSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50275241   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Perforin-1


(Homo sapiens (Human))
BDBM50275241
PNG
((Z)-6-Methyl-1-((5-phenylfuran-2-yl)methylene)-4-t...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1ccc(o1)-c1ccccc1
Show InChI InChI=1S/C19H13NO3S/c1-11-9-14-16(23-19(21)17(14)18(24)20-11)10-13-7-8-15(22-13)12-5-3-2-4-6-12/h2-10H,1H3,(H,20,24)/b16-10-
NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay


J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair