BDBM50275770 CHEMBL513568::N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(2,8-diazaspiro[4.5]decan-8-yl)nicotinamide

SMILES Nc1ccc(cc1NC(=O)c1ccc(nc1)N1CCC2(CCNC2)CC1)-c1cccs1

InChI Key InChIKey=CHKGICCHQYDKNR-UHFFFAOYSA-N

Data  1 KI  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50275770   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275770(CHEMBL513568 | N-(2-amino-5-(thiophen-2-yl)phenyl)...)
Affinity DataKi:  790nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275770(CHEMBL513568 | N-(2-amino-5-(thiophen-2-yl)phenyl)...)
Affinity DataEC50:  1.00E+4nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275770(CHEMBL513568 | N-(2-amino-5-(thiophen-2-yl)phenyl)...)
Affinity DataIC50:  1.26E+6nMAssay Description:Inhibition of human HDAC3 expressed in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275770(CHEMBL513568 | N-(2-amino-5-(thiophen-2-yl)phenyl)...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human HDAC1 expressed in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275770(CHEMBL513568 | N-(2-amino-5-(thiophen-2-yl)phenyl)...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human HDAC2 expressed in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed