BDBM50276074 CHEMBL470791::HDAC inhibitor, Compound 2::N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(1-oxo-2,7-diazaspiro[3.5]nonan-7-yl)nicotinamide
SMILES Nc1ccc(cc1NC(=O)c1ccc(nc1)N1CCC2(CNC2=O)CC1)-c1cccs1
InChI Key InChIKey=BHUJWKLXOJFZOZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50276074
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: 1.10E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 53.8nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of human HDAC1 expressed in mammalian cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.40E+3nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataKd: 24.6nMpH: 8.0Assay Description:Specifically, the experiments were conducted in black 384-well polypropylene plates (Corning Glass) in a 15-ul reaction volume consisting of 11 nM HD...More data for this Ligand-Target Pair
Affinity DataKd: 48.1nMpH: 8.0Assay Description:Specifically, the experiments were conducted in black 384-well polypropylene plates (Corning Glass) in a 15-ul reaction volume consisting of 11 nM HD...More data for this Ligand-Target Pair
Affinity DataIC50: 7.93nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair