BDBM50276077 CHEMBL469950::N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl)nicotinamide

SMILES Nc1ccc(cc1NC(=O)c1ccc(nc1)N1CCC2(CC1)NCNC2=O)-c1cccs1

InChI Key InChIKey=MBPWBRLIXYHMKP-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50276077   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50276077(CHEMBL469950 | N-(2-amino-5-(thiophen-2-yl)phenyl)...)
Affinity DataKi:  7.54E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50276077(CHEMBL469950 | N-(2-amino-5-(thiophen-2-yl)phenyl)...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human HDAC1 expressed in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed