BDBM50277190 (S)-6-methyl-N-(2-(thiazol-2-ylmethylamino)-2,3-dihydro-1H-inden-5-yl)-4'-(trifluoromethyl)biphenyl-2-carboxamide::CHEMBL474893

SMILES Cc1cccc(C(=O)Nc2ccc3C[C@@H](Cc3c2)NCc2nccs2)c1-c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=BDOBNHGYFGVFDD-QHCPKHFHSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50277190   

TargetSmoothened homolog(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277190((S)-6-methyl-N-(2-(thiazol-2-ylmethylamino)-2,3-di...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277190((S)-6-methyl-N-(2-(thiazol-2-ylmethylamino)-2,3-di...)
Affinity DataIC50:  140nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50277190((S)-6-methyl-N-(2-(thiazol-2-ylmethylamino)-2,3-di...)
Affinity DataIC50:  30nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed