BDBM50278226 2-chloro-4-(o-tolyloxy)benzonitrile::CHEMBL470204

SMILES Cc1ccccc1Oc1ccc(C#N)c(Cl)c1

InChI Key InChIKey=NOLQETBWRAYXMF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50278226   

TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278226(2-chloro-4-(o-tolyloxy)benzonitrile | CHEMBL470204)
Affinity DataIC50: 30nMAssay Description:Displacement of [3H]DHT from human cloned androgen receptor expressed in insect Sf9 cell systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278226(2-chloro-4-(o-tolyloxy)benzonitrile | CHEMBL470204)
Affinity DataIC50: 57nMAssay Description:Antagonist activity at Androgen receptor in human MDA-kb2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278226(2-chloro-4-(o-tolyloxy)benzonitrile | CHEMBL470204)
Affinity DataIC50: 57nMAssay Description:Antagonist activity at human androgen receptor expressed in human MDA-MB-231 cells assessed as inhibition of DHT-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278226(2-chloro-4-(o-tolyloxy)benzonitrile | CHEMBL470204)
Affinity DataIC50: 60nMAssay Description:Binding affinity to human Androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed