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BDBM50279103 5-(thiophen-2-ylsulfonyl)-5H-dibenzo[b,d]azepin-7(6H)-one::CHEMBL497249

SMILES: O=C1CN(c2ccccc2-c2ccccc12)S(=O)(=O)c1cccs1

InChI Key: InChIKey=YORIAFCWXUMHOS-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50279103   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50279103
PNG
(5-(thiophen-2-ylsulfonyl)-5H-dibenzo[b,d]azepin-7(...)
Show SMILES O=C1CN(c2ccccc2-c2ccccc12)S(=O)(=O)c1cccs1
Show InChI InChI=1S/C18H13NO3S2/c20-17-12-19(24(21,22)18-10-5-11-23-18)16-9-4-3-7-14(16)13-6-1-2-8-15(13)17/h1-11H,12H2
PDB

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UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.40E+3n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay


Bioorg Med Chem Lett 19: 2299-304 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.077
BindingDB Entry DOI: 10.7270/Q29K4B38
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50279103
PNG
(5-(thiophen-2-ylsulfonyl)-5H-dibenzo[b,d]azepin-7(...)
Show SMILES O=C1CN(c2ccccc2-c2ccccc12)S(=O)(=O)c1cccs1
Show InChI InChI=1S/C18H13NO3S2/c20-17-12-19(24(21,22)18-10-5-11-23-18)16-9-4-3-7-14(16)13-6-1-2-8-15(13)17/h1-11H,12H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.30E+4n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of cloned Kv1.3 channel (unknown origin) expressed in mammalian cells by whole cell patch clamp assay


Bioorg Med Chem Lett 19: 2299-304 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.077
BindingDB Entry DOI: 10.7270/Q29K4B38
More data for this
Ligand-Target Pair