BDBM50279256 CHEMBL527018::D-2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(5-methyl-1H-indol-3-yl)propanoic acid::N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan

SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccc(C)cc12)C(O)=O

InChI Key InChIKey=SFVPXERGVLDWIS-OAQYLSRUSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50279256   

TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50279256(CHEMBL527018 | D-2-(4-(but-2-ynyloxy)phenylsulfona...)
Affinity DataIC50:  6.82E+3nMAssay Description:Inhibition of MMP14 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50279256(CHEMBL527018 | D-2-(4-(but-2-ynyloxy)phenylsulfona...)
Affinity DataIC50:  140nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50279256(CHEMBL527018 | D-2-(4-(but-2-ynyloxy)phenylsulfona...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of MMP1 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50279256(CHEMBL527018 | D-2-(4-(but-2-ynyloxy)phenylsulfona...)
Affinity DataIC50:  1.81E+3nMAssay Description:Inhibition of MMP13 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Mus musculus (Mouse))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50279256(CHEMBL527018 | D-2-(4-(but-2-ynyloxy)phenylsulfona...)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibition of TACE in mouse Raw264.7 cells assessed as inhibition of LPS-induced TNFalpha production treated 1 hr before LPS challenge measured 4 hrs...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50279256(CHEMBL527018 | D-2-(4-(but-2-ynyloxy)phenylsulfona...)
Affinity DataIC50:  270nMAssay Description:Inhibition of MMP2 by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed