BDBM50279256 CHEMBL527018::D-2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(5-methyl-1H-indol-3-yl)propanoic acid::N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan

SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N[C@H](Cc2c[nH]c3c2cc(cc3)C)C(=O)O

InChI Key InChIKey=SFVPXERGVLDWIS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50279256   

LigandPNGBDBM50279256(D-2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(5-meth...)
Affinity DataIC50: 140nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50279256(D-2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(5-meth...)
Affinity DataIC50: 270nMAssay Description:Inhibition of MMP2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50279256(D-2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(5-meth...)
Affinity DataIC50: 1.81E+3nMAssay Description:Inhibition of MMP13 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50279256(D-2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(5-meth...)
Affinity DataIC50: 6.82E+3nMAssay Description:Inhibition of MMP14 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50279256(D-2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(5-meth...)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of TACE in mouse Raw264.7 cells assessed as inhibition of LPS-induced TNFalpha production treated 1 hr before LPS challenge measured 4 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50279256(D-2-(4-(but-2-ynyloxy)phenylsulfonamido)-3-(5-meth...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MMP1 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed