BDBM50281657 CHEMBL434492::Candoxatrilat::candoxatrilate::cis-4-[({1-[(2S)-2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentyl}carbonyl)amino]cyclohexanecarboxylic acid

SMILES COCCOC[C@H](CC1(CCCC1)C(=O)N[C@H]1CC[C@H](CC1)C(O)=O)C(O)=O

InChI Key InChIKey=ACZWIDANLCXHBM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50281657   

TargetNeprilysin(Human)
Birla Institute of Technology and Sciences Pilani

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50281657BDBM50281657(cis-4-[({1-[(2S)-2-carboxy-3-(2-methoxyethoxy)prop...)
Affinity DataKi:  6.10nMAssay Description:Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetNeprilysin(Human)
Birla Institute of Technology and Sciences Pilani

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50281657BDBM50281657(cis-4-[({1-[(2S)-2-carboxy-3-(2-methoxyethoxy)prop...)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetNeprilysin(Rat)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50281657BDBM50281657(cis-4-[({1-[(2S)-2-carboxy-3-(2-methoxyethoxy)prop...)
Affinity DataIC50: 38nMAssay Description:The compound was tested for its inhibitory activity against neutral endopeptidase (EC.3.4.24.111) in rat kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article