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BDBM50282455 CHEMBL169967::Quinazolinone Analog

SMILES: CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1

InChI Key: InChIKey=WPFDTJYMQILCJX-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50282455   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II AT2


(RAT)
BDBM50282455
PNG
(CHEMBL169967 | Quinazolinone Analog)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
Show InChI InChI=1S/C34H41N5O6S/c1-6-8-20-45-34(42)37-46(43,44)30-13-10-9-12-27(30)25-16-14-24(15-17-25)22-39-31(11-7-2)36-29-19-18-26(21-28(29)32(39)40)35-33(41)38(5)23(3)4/h9-10,12-19,21,23H,6-8,11,20,22H2,1-5H3,(H,35,41)(H,37,42)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 3.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282455
PNG
(CHEMBL169967 | Quinazolinone Analog)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
Show InChI InChI=1S/C34H41N5O6S/c1-6-8-20-45-34(42)37-46(43,44)30-13-10-9-12-27(30)25-16-14-24(15-17-25)22-39-31(11-7-2)36-29-19-18-26(21-28(29)32(39)40)35-33(41)38(5)23(3)4/h9-10,12-19,21,23H,6-8,11,20,22H2,1-5H3,(H,35,41)(H,37,42)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 0.210n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane


Bioorg Med Chem Lett 4: 81-86 (1994)


Article DOI: 10.1016/S0960-894X(01)81126-4
BindingDB Entry DOI: 10.7270/Q2D79BBS
More data for this
Ligand-Target Pair